STAFF PROFILE
Mrs. Narin Osman
Position:
Senior Lecturer
College / Portfolio:
STEM College
School / Department:
STEM|Health and Biomedical Sciences
Phone:
+61399256686
Email:
narin.osman@rmit.edu.au
Campus:
Bundoora West
Contact me about:
Research supervision
Research interests
- Cell signaling pathways that regulate extracellular matrix form and function with a focus on vascular disease and diabetes.
- Cell biology of proteoglycans and glycosaminoglycans in health and disease.
- Identification of drug targets for the prevention of cardiovascular diseases and diabetes.
Professional association
- International Society for Matrix Biology, member
- Australian Vascular Biology Society, member
- 2008 – current Diabetes Research Trust Grant, grant assessor
- 2010 – current Journal of Cardiovascular Translational Research, reviewer
- 2012 – current NHMRC, grant assessor
Grants
- NHMRC Project Grant 2012 - 2014
- National Heart Foundation of Australia, 2011/12, 2010/11, 2007/8
- Diabetes Australia Research Trust. 2009, 2008
- NHMRC Development Grant (2007-08)
Summary of activities
Senior Research Fellow and Deputy Group Leader, Diabetes Complications Group, Health Innovations Research Institute
Teaching responsibilities
Supervision of undergraduate research placement students, post-graduate Honours, Masters and PhD students.
Academic management and administration responsibilities
- Member, School of Medical Sciences Research Committee
- Research representative, Discipline of Pharmacy
- Member, RMIT Institutional Biosafety Committee
- B.Sc (Hons), University of Melbourne, 1984
- PhD, University of Melbourne, 1988
- Graduate Certificate (Computing), Monash University, 2002
- Sarkar, S.,Osman, N.,Thrimawithana, T.,Wann, S.,Kalita, J.,Manna, P. (2024). Alleviation of Diabetic Retinopathy by Glucose-Triggered Delivery of Vitamin D via Dextran-Gated Functionalized Mesoporous Silica Nanoparticles In: ACS Applied Bio Materials, 7, 1260 - 1270
- Kamato, D.,Gabr, M.,Kumarapperuma, H.,Chia, Z.,Zheng, W.,Xu, S.,Osman, N.,Little AM, P. (2022). Gaq Is the Specific Mediator of PAR-1 Transactivation of Kinase Receptors in Vascular Smooth Muscle Cells In: International Journal of Molecular Sciences, 23, 1 - 13
- Kamato, D.,Do, B.,Osman, N.,Ross, B.,Mohamed, R.,Xu, S.,Little, P. (2020). Smad linker region phosphorylation is a signalling pathway in its own right and not only a modulator of canonical TGF-ß signalling In: Cellular and Molecular Life Sciences, 77, 243 - 251
- Kamato, D.,Burch, M.,Zhou, Y.,Mohamed, R.,Stow, J.,Osman, N.,Zheng, W.,Little, P. (2019). Individual Smad2 linker region phosphorylation sites determine the expression of proteoglycan and glycosaminoglycan synthesizing genes In: Cellular Signalling, 53, 365 - 373
- Kamato, D.,Ta, H.,Afroz, R.,Xu, S.,Osman, N.,Little, P. (2019). Mechanisms of PAR-1 mediated kinase receptor transactivation: Smad linker region phosphorylation In: Journal of Cell Communication and Signaling, 13, 539 - 548
- Rabah, S.,Gowan, I.,Pagnin, M.,Osman, N.,Richardson, S. (2019). Thyroid Hormone Distributor Proteins During Development in Vertebrates In: Frontiers in Endocrinology, 10, 1 - 8
- Rostam, M.,Shajimoon, A.,Kamato, D.,Mitra, P.,Piva, T.,Getachew, R.,Cao, Y.,Zheng, W.,Osman, N.,Little AM, P. (2018). Flavopiridol inhibits TGF-ß-stimulated biglycan synthesis by blocking linker region phosphorylation and nuclear translocation of Smad2536 In: Journal of Pharmacology and Experimental Therapeutics, 365, 156 - 164
- Afroz, R.,Cao, Y.,Rostam, M.,Ta, H.,Xu, S.,Zheng, W.,Osman, N.,Kamato, D.,Little AM, P. (2018). Signalling pathways regulating galactosaminoglycan synthesis and structure in vascular smooth muscle: Implications for lipoprotein binding and atherosclerosis In: Pharmacology & Therapeutics, 187, 88 - 97
- Talati, N.,Kamato, D.,Piva, T.,Little, P.,Osman, N. (2018). Thrombin promotes PAI-1 expression and migration in keratinocytes via ERK dependent Smad linker region phosphorylation In: Cellular Signalling, 47, 37 - 43
- Kamato, D.,Bhaskarla, V.,Mantri, N.,Oh, T.,Ling, D.,Janke, R.,Zheng, W.,Little AM, P.,Osman, N. (2017). RNA sequencing to determine the contribution of kinase receptor transactivation to G protein coupled receptor signalling in vascular smooth muscle cells In: PLoS One, 12, 1 - 28
- New strategy for managing diabetic retinopathy - evaluation of somatostatin formulations. Funded by: 111-Diabetes Australia Research Trust Grant 2018 from (2018 to 2019)
- Receptor transactivation in vascular disease. Funded by: National Health and Medical Research Council (NHMRC) Project Grant Pre-2014 from (2012 to 2015)
- NHMRC Standard Equipment Grant 2012. Funded by: NHMRC Equipment Only Grants from (2012 to 2012)
- Linker region phosphorylated Smad2 as a novel target for the prevention of atherosclerosis. Funded by: National Heart Foundation of Australia Grants-in-Aid Grant Pre-2014 from (2011 to 2012)
- PDGF receptor tyrosine activity in the regulation of proteoglcyan synthesis invascular smooth muscle. Funded by: National Heart Foundation of Australia Grants-in-Aid Grant Pre-2014 from (2010 to 2011)
Note: Supervision projects since 2004
6 PhD Completions
Cell signalling, proteoglycan biochemistry, pathology and cell biology of cardiovascular diseases especially atherosclerosis and diabetes-related vascular disease.