Jiali (Maggie) Zhai

Associate Professor Jiali (Maggie) Zhai

Associate Professor

Details

Open to

  • Masters Research or PhD student supervision

About

Dr Jiali (Maggie) Zhai is an Associate Professor of chemistry in School of Science, and is one of the HDR managers within the school. Her research seeks to solve outstanding biomedical problems by developing responsive and composite nanomaterials and innovate in value added foods by advancing food colloidal systems.

Dr Jiali (Maggie) Zhai obtained her PhD at Monash University in 2013. Before joining RMIT, she was awarded the CSIRO Office of Chief Executive Postdoctoral Fellowship in 2015. Her primary research interests include lipid nanoparticle drug delivery systems, mRNA delivery, hydrogels and microgels, amphiphile self-assembly, liquid crystals, ionic liquids, and nano-bio interactions. Her research also takes an applied and multidisciplinary approach to solve outstanding biomedical problems such as nanotechnology-enabled targeted drug delivery, biomedical imaging, protein and gene delivery, and functional food colloids. She has been awarded two ARC Discovery Projects, and one mRNA Victoria grant to innovate in lipid nanoparticle drug delivery technology. 

In 2020, Maggie was awarded the Victoria Fellowship to undertake a study mission of designing super-swollen lipid nanoparticles for protein and gene delivery in four European countries and two European synchrotron facilities. In 2023, she was awarded the ANSTO Research Award. She is also a recipient of the Australian Academy of Science European Mobility Grant 2025. Maggie has strong expertise in synchrotron-based techniques such as small angle X-ray scattering (SAXS, bioSAXS) and circular dichroism (CD) techniques, which she uses to develop new methods to study self-assembly in biologically relevant systems, and the structures of mRNAs and proteins at membrane interface.

 

Maggie currently serves as the Chair of the Australian Synchrotron User Advisory Committee (UAC) and the Treasurer of the Australasian Colloids and Interface Society. 

Academic positions

  • Secondment - Intellectual Property and Commercialisation Team
  • RMIT University
  • Research & Innovation Portfolio
  • Melbourne, Australia
  • 1 Jan 2017 – 31 Dec 2018

Supervisor projects

  • Developing bile salt and ionic liquid-lipid nanocomplex for oral delivery of nucleic acid
  • 24 Jan 2025
  • Investigating physicochemical and toxic properties of lipid nanoparticles as prospective drug carriers
  • 23 Jan 2025
  • Carbon Dot-based Hydrogel Multifunctional Platforms for Biosensors
  • 25 Nov 2024
  • External Stimulation of Stem Cells for Tissue Engineering
  • 28 Feb 2024
  • Developing organ-targeted lipid nanoparticles for mRNA delivery
  • 22 Feb 2024
  • Developing organ-targeted lipid nanoparticles for mRNA delivery
  • 20 Nov 2023
  • Floating photocatalytic membrane device for hydrogen generation from seawater
  • 2 May 2023
  • Reversible carbon dioxide conversion for clean energy production
  • 14 Feb 2023
  • Develop advanced injectable bioactive hydrogels for improving tissue regeneration
  • 9 Dec 2022
  • Novel Responsive Lipid Nanoparticles for Multidrug-Resistant Organism Therapeutics
  • 24 Aug 2022
  • Developing novel ALOX5 mRNA nanoparticles to treat incurable non-small cell lung cancer
  • 24 Feb 2022
  • Self-assembled Lipid Nanoparticles for Targeted Cancer Therapeutics
  • 7 Apr 2021
  • Biocompatible Ionic Liquids as Designer Solvents for Non-lamellar Lyotropic Liquid Crystalline Nanoparticles
  • 9 Jun 2020
  • Development and Application of Novel pH-responsive Lipid Nanoparticles for Anticancer and Antifungal Drug Delivery
  • 2 Dec 2019
  • Molecular Insights into Amyloid Toxicity Using Model Lipid Membranes
  • 2 Mar 2015

Teaching interests

Teaching
Food Chemistry (CHEM 1083/1226)
Food Manufacturing (ONPS 2533/2546)

Science Project supervisor

Research interests

Physical Chemistry (incl. Structural), Nanotechnology, Lipid Nanoparticles, mRNA Therapeutics, Colloids and Interface Science, Macromolecular and Materials Chemistry, Food Sciences, Medicinal and Biomolecular Chemistry, Other Chemical Sciences

Research
Multiple projects in nanobiotechnology, nanoparticle drug delivery, mRNA delivery, hydrogel, microgel, and functional food colloids
Supervision of HDR students

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Acknowledgement of Country

RMIT University acknowledges the people of the Woi wurrung and Boon wurrung language groups of the eastern Kulin Nation on whose unceded lands we conduct the business of the University. RMIT University respectfully acknowledges their Ancestors and Elders, past and present. RMIT also acknowledges the Traditional Custodians and their Ancestors of the lands and waters across Australia where we conduct our business - Artwork 'Sentient' by Hollie Johnson, Gunaikurnai and Monero Ngarigo.